General:

• Route Markers were colored yellow, white, & black, similar to the yellow & white Route Markers of Season 1 (and in contrast to the yellow & red of all other seasons).
• The show said there were only two Yields, but there was another Yield on Leg 1 that didn't make it to air since it was not used.
• As with Season 7, the winners of the race were revealed in an online betting scandal well before the airing of the final episode.
• In Australia, the 9th Season was shown before this season in early 2006. This series was premiered on Thursday the 9th of November at 9:30pm on the Seven Network.
• According to Wally Bransen, an 11th Family (Flanders) were supposed to be on the race but were axed the last minute. The cause for this remains unknown.

Pre-Race:

• In March 2005, host Phil Keoghan toured major cities in the United States (Cleveland, Detroit, Chicago, St. Louis, Kansas City, Denver, Albuquerque, Phoenix, and Los Angeles) to scout contestants for the race. Final casting interviews took place in Las Vegas.

In-Race:

• For this race, the supplied credit card covers not only airfare, but also gasoline. Previously, gasoline had to be purchased with the supplied cash. The rule change was made necessary by the fact that most of the transportation takes place in cars rather than airplanes.
• The limits on individual Roadblock attempts, found in seasons 6 and 7, did not apply to this season. Furthermore, some roadblocks in this edition required the participation of two team members. Also, for the first time since season 5, a mid-race leg (4) was aired without a Roadblock.
• Kevin and Drew from Season 1 appeared in the first leg of the race handing out clues for teams in New York at a hot dog stand.
• In Leg 1, Renee Rogers fell at the starting line and suffered a concussion. The Rogers family didn't realize the severity of the injury until they had gone to a hospital after being eliminated from the race.
• In Leg 4, The Paolo family, after finishing a task involving partybikes, rode on their vehicle and saw a thunderstorm associated with the remnants of Hurricane Dennis outside Talladega Superspeedway.
• At the end of Leg 4, the Schroeder family was eliminated in New Orleans, their hometown. One month after the end of the race, their home was severely damaged by Hurricane Katrina (see below).
• In Leg 6, at Poás Volcano, the clue envelope appeared to contain Fast Forward instructions; however, this was not mentioned or described, perhaps because no team took advantage, or because plans for the task fell through. The Fast Forward in Leg 5 was introduced as the only one in the race when the show was televised. An online source claims that the task was simply not used, and all references were excised.
• According to an interview with Wally Bransen on RFFRadio, Hurricane Emily forced producers to cancel a leg in Belize. Teams had an extra day off in Costa Rica after Leg 6.
• A camera error occurred in Leg 9 (not shown) causing the Godlewski Family's car battery to fail, moving them into last place at the time. Another error, exactly the same as the one in Leg 9, occurred in Leg 10 (also not shown) affecting the Linz Family, also causing them to move into last place at the time.
• Linda Weaver wore a T-Shirt with the name "Chris" on it for many legs of the race. Contrary to popular belief, Chris was not the name of her late husband, but her fiancé.
• In a RFF Radio podcast interview with Wally Bransen, he said that the Linzs beat them to the finish mat by one or two minutes in the final leg therefore making it the third closest finish ever. The Weavers finished in third place a "hour or two" later.
• Linda Weaver reluctantly participated in two challenges directly related to racing. One was a go-kart race in Arizona, and the other involved traveling around Talladega Superspeedway in a bicycle. Weaver's husband, Roy, was killed in an accident when he was run over by a race car at Daytona International Speedway in 2004.
• The Weavers were the first team in TAR history to be Yielded twice in the same race (out of three possible times in the race; the 3rd Yield was not used here). Although they finished last in the leg after being yielded the second time, they were saved by a non-elimination situation.

Post-Race:

• After the Linz family were named the official winners, it was revealed that the Bransen and Weaver Families would compete in the "Final Amazing Challenge". The two families would race back and forth between the last roadblock of the race (a map of North and Central America) and a set of 12 clueboxes, each of which contained an icon, representing something the families did on the race. The object of the challenge was to race (as a family) out to the clueboxes, get the icons one at a time, and then place them on the appropriate place on the map. Whichever team finished this challenge first would win a brand new GMC Yukon XL, the same vehicle that had been used on the race. The Bransen family won the challenge and the vehicle.
• The Schroeder family evacuated their New Orleans home due to Hurricane Katrina and stayed with the Rogers family in Shreveport, Louisiana for a short period of time. Denny Rogers even supplied a truck to help the Schroeders evacuate the flood-ravaged area. The Schroeder home was seriously damaged and was being rebuilt at the time of the show's airing.
• Production staff visited a Moab, Utah diner during the shooting of Leg 9. They inadvertently left behind papers including the full text of that leg's clues
• Billy and Carissa Gaghan wrote introductions for "My Ox is Broken", a book about the Amazing Race.