• This season featured many Olympic themed challenges such as water polo, track and feild, swimming, and archery. The race also visited past Olympic cities including Oslo, Stockholm, and Berlin. This was due to the fact that the race was filmed during the same time as the 2004 Summer Olympics in Athens, Greece.

Pre-Race:

• Models Freddy & Kendra knew other models from previous editions of the race: Derek and Drew from Season 3 and Kelly & Jon from Season 4. Freddy and Kendra actually used the same backpacks that Kelly & Jon used in Season 4.
• Don & Mary Jean were chosen for the race after an open casting call in San Diego.
• Victoria had a cameo appearance on Whose Line is it Anyway?
• Early Show hosts Harry Smith and Dave Price ran the first leg of the race (USA-Iceland) with the actual teams. This was for a special segment on their morning show.

In-Race

• Lena & Kristy were the first team to be eliminated by way of not being able to complete a roadblock (but not giving up); Phil told Lena & Kristy that the last team had checked in over 2 hours previous, and Lena still had not found the clue after rolling out 100 haybales over the course of 8 hours.
• Aaron Goldschmidt of Season 3 accidentally stumbled upon one of the Pit Stops while backpacking in Europe.
• There were 36 hour pit stops in Stockholm, Sweden (after Lena & Kristy were eliminated at the farm on the night); Budapest, Hungary; Ethiopia and Xi'an, China.
• Leg 2 featured the first task ever on The Amazing Race that required interteam cooperation. The ten teams had to split themselves into two groups of five, each of which had to row a Viking boat across a fjord to a marked dock with a clue box. The next time teams had to work together didn't come until the Season 10, when a task called an "Intersection" required two teams to work together.
• Leg 6 was originally planned as two separate legs with the first leg being a non-elimination point (with the losing team being stripped of their money), but combined into one after producers realized that begging was prohibited in Hungary.
• In Leg 8, the check-in mat was a tan colored mat made of cloth with a map of the world shown in black, instead of green.
• In Leg 9, Adam & Rebecca arrived at the pitstop in second, but they forgot to swim in the pool. This dropped them to 4th.
• In Leg 11, Hayden & Aaron arrived third, in front of Adam & Rebecca, but were eliminated because they had taken a four hour time penalty for not completing the roadblock. Both Rebecca and Hayden almost had to quit the roadblock because the last gondola down the mountain was about to leave. The task was to search approximately 3,000 locks and find the one that opened with a key they were given. At the last moment, when Hayden & Aaron decided to quit, Rebecca opened her lock.
• At the Pit Stop of the Leg 11, Aaron proposed to Hayden. She accepted.

Post-Race:

• Post-game interviews suggested that Kris & Jon were less than a minute behind winners Freddy and Kendra before a trian held them up at a railway crossing. At thefishboul.com, Bolo suggested that Kris & Jon were only 30-40 seconds behind Freddy & Kendra to the finish. At RealityReel, Kristy said that "Right after Freddy & Kendra started running, literally within 30 seconds or a minute later the train came, and Kris & Jon arrived. Otherwise it would have come down to a neck to neck race." This would be the Race's second closest finish ever, after Season 2.
• The trains that carried the teams in Sri Lanka and the town of Galle were heavily damaged by the tsunami caused by the 2004 Indian Ocean earthquake.
• Kristy Jensen (of Lena & Kristy) appeared in Disney's made for TV movie "Read It And Weep" as soap star Cadyn Christopher.
• After the controversial shoving episode, married couple Jonathan Baker and Victoria Fuller appeared on a Dr Phil special to try and improve their marriage. A subsequent appearance on the show Fear Factor in which Victoria attacked fellow contestant Jon "Johnny Fairplay" Dalton (of Survivor: Pearl Islands Panama) and Jonathan attacked the host Joe Rogan, resulting in their premature departure from the show, served to illustrate that their relationship remains fiery.
• The Amazing Race 6 was one of the three seasons not represented in The Amazing Race All-Stars, the other two were THE AMAZING RACE 4 and THE AMAZING RACE 8: FAMILY EDITION. It is not clear, however, if TAR8 members were even considered for All-Stars because of the four-team structure of the teams; it is possible that a new two-person combination was considered along the lines of the Eric-Danielle team, but whether this was an option is unknown.
• Hayden & Aaron got married on April 21, 2007. Kristy was a bridesmaid, and Kris and Jon were present among the guests.
• Freddy & Kendra got married, and now have a child named Jaxson.