General:

• This is the first season to (nearly) circumnavigate the globe in a generally westwardly fashion, crossing the Pacific Ocean in the first leg and crossing the Atlantic on the final leg. Most other seasons (with the exception of Season 7 and Season 8) tranversed the globe in a generally eastwardly direction; the first legs of these races had teams crossing the Atlantic Ocean or staying on the North America/South America landmass, and then crossing the Pacific on the final legs.
• Sarah reported in a post-race interview on The Finish Line that because of the Roadblock in the first leg a single team member could do a maximum of 7 Roadblocks instead of the usual 6 (as has been in place from Season 6). This rule was never mentioned on the show, although Karlyn performed 7 aired Roadblocks.
• A Fast Forward was offered in conjunction with the Intersection in Leg 8. Mary reported in a post-race interview on The Finish Line that a team could use a Fast Forward for a second time (in this case with a team that had not used a Fast Forward earlier in the race). In previous seasons, teams were allowed to use only one Fast Forward during the entire race. Her reports were proven to be true in The Amazing Race 11, where one team was able to use both the Fast Forward while being intersected with another team and another individual Fast Forward on the race.

Pre-Race:

• Tyler Denk and James Branaman were close friends of Survivor: Panama winner, Aras Baskauskas.

In-Race:

• During the first leg, Bilal and Sa'eed were eliminated when they arrived last at a checkpoint in the middle of the leg, the first and so far only time a team has ever been eliminated before a leg's official pit-stop end location.
• In Leg 3 and Leg 4 (Vietnam), all route markers were white and yellow instead of red and yellow. This was done because the flag of the vanquished South Vietnam also consisted of red and yellow stripes. This is similar to Season 3's Leg 11 in which the teams traveled through Ho Chi Minh City and Da Nang, however, the route markers were made solid yellow in that season. Additionally, teams were not allowed to ride on motorbikes for safety reasons. At the beginning of Leg 3, teams were not given any money and were not permitted either to beg for money or to sell items. Instead, they had to earn money in the Roadblock. At the beginning of Leg 4, teams received 588,000₫ (dong VND - approximately USD $37) at the start of the leg. This was the first time in race history the cash distribution was made in a currency in other than US dollars.
• A Yield was available in one of the Vietnam legs, either Leg 3 or Leg 4, but was not used or aired, according to Mary on The Finish Line. David & Mary were apparently the first team on the Yield mat, so it is speculated that the Yield could have been before the Roadblock in Leg 4.
• During Leg 6, Peter and Sarah's car had a handicap sticker from the state of California.
• Peter and Sarah did not arrive at Leg 6's Pit Stop until after David and Mary departed at the beginning of Leg 7.
• While no Roadblock was shown for Leg 7, a Roadblock clue is clearly visible in Dustin and Kandice's hands in one of the stills for the episode on the show's website.
• The prize for Leg 10 was given to the team that selected the "good luck charm" earlier in the leg that happened to match the one worn by the greeter at the pit stop. Unlike most former luck prizes, however, this one was awarded to the winners of the leg.

Post-Race:

• David and Mary appeared on The View. David revealed that he had originally auditioned for Survivor. The couple also received gifts from the show, including vacations, a Ford Explorer, and a new house.
• Just prior to returning to New York City for the post-race interview circuit, Lyn's house was ransacked.
• David & Mary and Dustin & Kandice were selected to race in The Amazing Race All-Stars.
  • Notably, Dustin and Kandice did not make the usual interview tours after their elimination in this race for the first time, as they were still racing in All-Stars when the episode in which they were eliminated aired.
• Dustin married her high school sweetheart prior to the start of All-Stars. In the pre-race interviews for All-Stars, Dustin states that Kandice was a bridesmaid at her wedding, which she might not have been had they not run the Season 10 Race together.
• Dustin & Kandice received a letter from Lyn during All-Stars as part of a Roadblock task. A video of Karlyn yelling at Dustin & Kandice at an airport ticket counter during Season 10 was shown in the episode.
• Peter Harsch (of Peter & Sarah) now works as a prosthetist at Navy Medical Center San Diego.
• Episode 4 which contained Leg 4 was selected by CBS for The Amazing Race nomination in the 2007 Emmy Awards. And subsequently garnered 5 total nominations, including one for the Outstanding Reality-Competition Program. The episode won the latter award, winning for the show its 5th Outstanding Reality-Competition Award in a row.